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Am J Physiol 1991

TGF-, PDGF, EGF, and FGF have been shown to stimulate infiltration of inflammatory cells into the wound space.24 These growth factors induce proliferation of keratinocytes and fibroblasts, lead to new formation of capillaries in the granulation tissue, and modulate extracellular matrix deposition and reconstitution of the injured area.25 The topical application of growth factors was successful in accelerating healing of full-thickness wound in normal mice.8,9 The pentadecapeptide body protective compound (BPC)-157 ( Mr 1419), with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, a 15-amino acid fragment of the BPC peptide in gastric juice, is thought to be essential for BPCs activity and has been fully characterized and investigated

Complete healing occurred in 73% of patients within 8 weeks, compared to 41% in the control group receiving standard care