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Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance

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The AMYRs are located in the AP on DBH positive neurons 15 and Calcr neuronal populations do express other receptors such as the GLP-1R or GFRAL

If approved, CagriSema would provide patients and healthcare professionals with an additional treatment option supported by results from the REDEFINE clinical program, including robust efficacy, high treatment completion rates, and a tolerability profile consistent with its underlying pharmacology