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Induction of this biosynthetic pathway enhances intracellular GSH levels and promotes cancer cell resistance to ferroptosis, 142,143 whereas pharmacological inhibition of GSH synthesis by L-buthionine-(S,R)-sulfoximine (BSO), a GCL inhibitor, induces ferroptosis 144

Tumor heterogeneity adds complexity, as cancer cells vary in their susceptibility to ferroptosis (Liang et al., 2019) and cuproptosis, allowing some cells to evade death or develop resistance by enhancing antioxidant defenses or modulating metal metabolism

Oral Dosing Guide Because there are no human trials, there is no established human dose, schedule, or validated route for Dihexa

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