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Chan GC, Hinds TR, Impey S, Storm DR: Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol

The burden of these diseases on healthcare systems and patients is significant, and there is a growing need for innovative and effective treatments that can improve patient outcomes and quality of life

FIGURE 2 3.1 Gut-immune axis The gut microbiota plays a critical role in the development and regulation of the host immune system through metabolites such as SCFAs contributes to host immune regulation via multiple mechanisms-including G-protein couples receptor (GPCR) signaling (e.g., GPR43/41), histone deacetylase (HDAC) inhibition and cytokine modulation-one of which involves the context dependent balance of Th17 and regulatory T (Treg) cells to support immune homeostasis in physiological states (83, 84) and diseases like rheumatoid arthritis (RA) or autoimmune hepatitis (AIH) (85, 86)

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