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Activation of microglia, resulting in the release of proinflammatory cytokines and the recruitment of astrocytes, has been observed in animal models of ALS (267)

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A 2023 phase II trial in 40 post-surgical patients found 0.5% GHK-Cu gel reduced scar volume by 35% at 3 months versus silicone (p=0.002) (Hosokawa et al., 2023)