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[59] reported that individuals at stages IIIV of chronic kidney disease exhibit significantly reduced urine levels of S-adenosylmethionine and SAM/S-adenosylhomocysteine ratio, as well as a decreased cysteine/homocysteine ratio in blood plasma in comparison to patients at stage II of CKD

Likewise, a negative correlation, as found between GSH production and cystine, denotes that a lower flux rate through the exchange reaction of the metabolitemore uptake or less secretionenables the model to produce GSH more rapidly