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The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells

Post-mortem and imaging studies further reveal deficits in electron transport chain complexes and pyruvate dehydrogenase activity, suggesting a mechanistic link between mitochondrial bioenergetics and ASD-related phenotypes

Categorizing patients into decade-based groups allows for a more systematic comparison and analysis across different age ranges, which is a commonly used approach in similar studies 20

Originally developed as an anti-obesity drug, AOD-9604 is a synthetic fragment derived from human growth hormone (hGH), specifically the 177-191 amino acid sequence