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Archived from the original on July 14, 2018

The exploration of macrocycles for drug discoveryan underexploited structural class

In contrast, treatment with Pd1 + Pd2 + SA resulted in a concentration-dependent decrease in spheroid size

Our mutational analysis indicates that the S114A mutant accumulates in the nucleus, suggesting that S114 phosphorylation is required for nuclear exit and subsequent phosphorylation by KIN-19