Travis WD, Dacic S, Wistuba I, Sholl L, Adusumilli P, Bubendorf L, Bunn P, Cascone T, Chaft J, Chen G, Chou TY, Cooper W, Erasmus JJ, Ferreira CG, Goo JM, Heymach J, Hirsch FR, Horinouchi H, Kerr K, Kris M, Jain D, Kim YT, Lopez-Rios F, Lu S, Mitsudomi T, Moreira A, Motoi N, Nicholson AG, Oliveira R, Papotti M, Pastorino U, Paz-Ares L, Pelosi G, Poleri C, Provencio M, Roden AC, Scagliotti G, Swisher SG , Thunnissen E, Tsao MS, Vansteenkiste J, Weder W, Yatabe Y
The aspartic acid residue is highly susceptible to dehydration, forming a cyclic imide that can then hydrolyze into either the original form or an inactive iso-aspartate analog
The disorder can be inherited although it is most often the result of a sporadic mutation in one of the parental gametes
PMID: 41080728 Biotin NHS purchased from MedChemExpress