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Estrogen enhances blood flow and increases skin thickness, moisture, and hydration through the production of hyaluronic acid, mucopolysaccharides, and sebum (Nikolakis et al., 2016

The most studied SH with regards to inflammation, 2,5-dimethoxy-4-iodoamphetamine (DOI), has been shown to profoundly suppresses TNF- mediated inflammation in rodent tissues at picomolar concentrationsequating to a dose in humans at least two orders of magnitude below what is necessary to produce hallucinogenic effects [185, 193, 194]

Maintenance dosing (typically IM glutathione 6001200mg every 24 weeks) sustains melanin reduction long-term

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