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Julien Roussel, [email protected] These authors have contributed equally to this work This article was submitted to Pharmacology of Ion Channels and Channelopathies, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Simultaneously, the combinatorial treatment also showed a significant decrease in the mRNA expressions of pro-inflammatory genes ( TNF- , IL-2 , INF- , TGF- , and VEGF ) known to be involved in the proliferation of cancer cells

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