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Separating this complex and potentially deadly internal gut content from our circulation and other organ systems, including the brain, is a tightly regulated interface consisting of a mucus layer, a single epithelial layer held together by tight junction proteins (e.g., zonulin and occludin), immunoglobulin A, defensins, and a carefully orchestrated immune surveillance in the lamina propria of the gut [136]

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Collectively, these dietary (exogenous) antioxidants assist the endogenous antioxidant system by scavenging radicals that were not removed by the endogenous antioxidant system

Supplementing with vitamin B12 is generally considered safe, as there is a low risk of toxicity