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Quality check: Discard the reconstituted solution if cloudiness, discoloration, or particulate matter appears

Do not stop abruptly without medical guidance, especially if you are also on diabetes medications

DECLARATIONS Authors contributions Drafted the manuscript: Valds-Calero I Revised the manuscript critically for important intellectual content: Rodrguez A, Frhbeck G All authors participated in final approval of the version to be published

Pharmacol Rev 54:101127 Talebi S, Bolhassani A, Azad TM, Arashkia A, Modaresi MH (2017) Immuno-stimulating peptide derived from HMGB1 is more effective than the N-terminal domain of Gp96 as an endogenous adjuvant for improvement of protein vaccines