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This is a conceptual argument rather than a measured one again, the human PK data do not exist but it illustrates why systemic delivery is not self-evidently advantageous for a cosmetic goal, and why the burden of proof sits squarely on anyone claiming injection is the better skin route

doi: 10.3389/fimmu.2024.1341600

The free radicals produced during fuel burning in the mitochondria can be compared to some of the waste products produced by a cars combustion engine, some of which are removed by the oil filter, Sekhar said