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Glutathione depletion in HIV-infected patients: Role of cysteine deficiency and effect of oral N-acetylcysteine

A pronounced reduction in melanin levels was observed in the VH032-Azi3 + Alk-TIn + SA cream group as a consequence of TYR degradation, which showed a 2.8-fold decrease than the blank cream treatment group, a 2.2-fold decrease than the epi-VH032-Azi3 + Alk-TIn + SA cream treatment group, and a 1.3-fold decrease than the DeTYR-3 group

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Curcumin has garnered extensive research attention for its medicinal properties (Lopresti, 2022)