Manipulation of genes encoding enzymes for, e.g., folate biosynthetic and salvage pathway, polyglutamylation, and folate binding proteins, has been carried out with some achievements 2,10,25,34,303,310,560,752,754,776,791,792,793,794,795,796,797,798,799,800,801,802
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Its unmatched strength lies in the ability to deliver an exceptionally high, conformal radiation dose directly to the tumor and involved cervix while minimizing exposure to surrounding healthy tissues [87]
Cysteine plays a role in the sulfation cycle, acting as a sulfur donor in phase II detoxification and as a methyl donor in the conversion of homocysteine to methionine [13-15]