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Cell 178 , 521535.e3 (2019)

Effect of antioxidant vitamin supplementation on endothelial function in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

These mechanisms include decreased expression of proteins that are key to mPTP formation, such as voltage-dependent anion channel (VDAC) and cyclophilin D (Cyp-D) [128], and the increased levels of nuclear factor erythroid-2 related factor 2 (Nrf2) [128], a transcription factor that is activated under stress conditions regulating the expression of antioxidant, anti-inflammatory, and detoxification enzymes that prevent mitochondrial impairment [131]

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