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While NAPQI is normally detoxified by glutathione, in APAP overdose, glutathione is depleted and NAPQI binds to cysteine on hepatic proteins as 3-(cystein- S -yl) APAP

Liver PSAT1 is required for SAAR-induced improvements in systemic glucose homeostasis To assess whether hepatic serine synthesis is essential for the metabolic benefits of dietary SAAR on glucose control, we studied liver-specific PSAT1 KO mice and WT littermates fed a HF-CTRL or -SAAR diet (Fig

(123) proposed a sample preparation method based on microwave assisted free radical degradation (MFRD) of plant polysaccharides to efficient degradation of S