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ABBREVIATIONS AD Alzheimer disease APP amyloid precursor protein ASH alcoholic steatohepatitis ETC electron transport chain Gpx glutathione peroxidase Grx glutaredoxin GSH glutathione GSSG oxidized glutathione GST glutathione- S -transferase IMM inner mitochondrial membrane mGSH mitochondrial glutathione MPT mitochondrial permeability transition NASH non-alcoholic steatohepatitis NO nitric oxide NPC NiemannPick type C disease OMM outer mitochondrial membrane OXPHOS oxidative phosphorylation Prx peroxiredoxin ROS reactive oxygen species SOD superoxide dismutase StARD1 steroidogenic acute regulatory domain 1 Trx thioredoxin