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2003 Oct 23;425(6960):805-11

The reasons are specific and addressable when identified early in the protocol

doi: 10.1038/nnano.2016.135 114 DalbethNCallanMF

Tissue growth and structural effects The mecasermin label also documents effects such as lymphoid tissue hypertrophy (including tonsillar and adenoidal enlargement) and reports of intracranial hypertension, reflecting IGF-1s broad growth-promoting activity across tissues rather than a muscle-specific action