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Metformin, known for its multifaceted beneficial properties, is acknowledged for its ability to counteract the adverse effects of increased oxidative stress at both molecular and cellular levels

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Thus, as is seen with leptin, glucocorticoids contribute to a reduced ability of insulin to inhibit NPY/AGRP neurons in the ARC, which has the converse effect of lessening appetite suppression ( Glucocorticoids also influence food intake by enhancing the preference for comfort foods. Insulins suppressive effect on reward pathways likely means the food needs to be more rewarding to achieve the same effect

Author contributions GM: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writingreview and editing