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United States Reissued Patent USRE42645 (E) Drakulic T, Temple MD, Guido R, Jarolim S, Breitenbach M, Attfield PV, Dawes IW (2005) Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae

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This cascade activates caspase-8 and downstream caspase-3 (Takahashi et al., 1999), leading to DNA fragmentation and keratinocyte apoptosis (Simon et al., 2006)

OS is a prevalent phenomenon in the brain in PD, resulting from an imbalance between the production of deleterious chemicals known as reactive oxygen species (ROS) and the brains capacity to neutralize them (34)