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Safety and side effects Most common side effect is GI distress and there have been some reported seizures when consumed at high doses as part of energy drinks in adolescents

Utilizing the recent advancements in science, a peptide similar to Epithalamin was synthesized and titled Epithalon. Epithalon is derived from a naturally occurring peptide belonging to both the pineal gland and eye retina

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The activation of two transcription factors, aryl hydrocarbon receptor (AhR, which is sensitive to ROS) and hypoxia-inducible factor (HIF)-1, which is responsive to the TCA metabolites succinate, were associated with an increase in IL-22 production