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Amantadine: A phase 3 trial was conducted to test the efficacy of the drug on alleviating dyskinesia and OFF time for PD patients and LD-induced dyskinesia

Monitoring includes regular glucose testing, IGF-1 levels, metabolic panels, insulin sensitivity markers, and clinical assessments

There are a handful of small early-phase studies in healthy adults showing that it raises GH and IGF-1 levels, but no large clinical trials in any defined patient group

Importantly, recent studies aimed at blocking the metaorganismal TMAO pathway through multiple approaches have confirmed the inhibition of diet-dependent atherosclerosis in animal models, either by targeting the initial microbial formation of TMA from choline through use of a nonlethal small-molecule inhibitor (19), or by targeting the second step in the pathway, the major host gene responsible for converting microbe-generated TMA into TMAO, flavin monooxygenase 3 (20, 21)