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Nomograms for prognostication of patients with esophageal and gastroesophageal carcinoma undergoing definitive chemoradiotherapy

[17] demonstrated that NAC led to a reduction in the extent of hepatic injury and to a subsequent improvement in brain function, the normalization of brain and hepatic glutathione levels, and a decrease in plasma pro-inflammatory cytokines, which may be clinically associated with a remission of organ dysfunctions in ALF

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Clinically, this points to a bi-directional interaction between gut inflammation and brain inflammation, with mast cells acting as key transducers in both arenas 24