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Moreover, these exosomes partially inhibit premature activation and depletion of primordial follicles by modulating the PI3K/AKT/mTOR signaling pathway, which is typically hyperactivated by chemotherapy, resulting in follicle burnout. Following treatment with hAEC exosomes, there is a reduction in the phosphorylation levels of critical proteins, including Akt and FoxO3a, which contributes to the preservation of ovarian reserve

doi: 10.1542/peds.2015-3684 550 KothariDPatelSKimS-K

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Sidestream-darkfield imaging A sophisticated tool for microcirculatory studies that uses concentrically positioned light-emitting diodes for illumination, which reduces image blurring and increases contrast