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Pilar Francino, [email protected] Present address: Alejandra Rey-MarioDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lcteos de Asturias (IPLA-CSIC), Oviedo, Spain;Diet, Microbiota and Health Group, Instituto de Investigacin Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Astaxanthin has been shown to increase BDNF levels studies in rodents and human cells (in vitro) Improvements in memory are observed in some studies but with variability across demographics These neurocognitive benefits may be through reduced lipid peroxidation Longevity pathways: Astaxanthin mechanistically modulates key longevity genes, including FOXO3, Sirt1, Klotho, and Nrf2

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