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reported that AS-IV can enhance the If current density in I/R-injured sinoatrial node cells, shorten APD at 20% and 50% repolarization in SAN cells, and upregulate HCN4 expression, thus helping maintain cell volume and cytoskeletal integrity in SAN cells, with potential therapeutic effects for sick sinus syndrome ( Calcium ion imbalance is a key contributor to the onset and progression of arrhythmia ( 2+ redistribution due to oxidative stress, inhibits calpain-1 activation, maintains calcium homeostasis, and prevents apoptosis in ISO-induced myocardial hypertrophy, reducing arrhythmia risk (Mei et al., 2015)