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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Beckman K.B., Ames B.N

FLSs then elicit overproduction of chemokines, cytokines, and matrix degradation molecules, thereby promoting immune cell infiltration and cartilage degradation [102]

Recently, more CSF biomarkers reflecting other biological processes in AD have emerged, such as axonal injury and synaptic dysfunction (NfL, neurogranin (NG), synaptosomal-associated protein 25, visinin-like protein 1), 366,367,372 neuroinflammation (TREM2, YKL40, S100B, glial fibrillary acidic protein (GFAP)), 371,376,377,378 changes in neurotrophic protein levels (BDNF and NGF), 379 BBB disruption (soluble platelet-derived growth factor receptor-), 380 and metabolic changes (sphingomyelin, ceramide, fatty acid-binding protein 3, ubiquitin C-terminal hydrolase L1)