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PKA directly phosphorylates sulfonylurea receptor 1 (SUR1), a regulatory subunit of voltage-dependent K + channels and KATP channels, increasing membrane depolarization and voltage-gated Ca 2+ channel activation

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DISCLOSURES: The authors report no conflicts of interest relevant to the content of this article

Firstly, given the evidence that glutathione and glutamate levels in the brain are affected by a risk variant of the gene coding for the glutathione synthesis enzyme, the role of genetic influences should be investigated [22]