Bladt F, Faden B, Friese-Hamim M, Knuehl C, Wilm C, Fittschen C, et al
indeed, higher circulating IGF-I concentrations are positively associated with a number of health parameters related to body composition and cardiovascular health, and negatively associated with body fat [3]
M.BrookesP
Several factors can reduce DAO levels or activity, including: Gut inflammation (due to infections, food intolerances, IBD, parasites) Leaky gut (increased intestinal permeability) Nutrient deficiencies (e.g., vitamin B6, vitamin C, copper, zinc) Medications (e.g., NSAIDs, antibiotics, antihistamines, antidepressants) Chronic stress Microbial imbalance (dysbiosis) Genetic polymorphisms affecting DAO gene expression Damage to the intestinal lining where DAO is produced is one of the most common contributors to low DAO activity and histamine intolerance