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Shifting perceptual aperture from small to vast (for example, moving from focusing on a leaf to the canopy to the sky/horizon) reliably evokes awe and can recalibrate arousal, time perception, and self-focus toward equanimity

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As Schwann cells are the most abundant glial cells in the peripheral nervous system, are major producers of both neurotrophins, and acquire a repairing phenotype after a nerve is damaged [68], it is plausible to hypothesize that the effects of cortistatin in neurotrophins are exerted through these cells