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Effect of siponimod on magnetic resonance imaging measures of neurodegeneration and myelination in secondary progressive multiple sclerosis: Gray matter atrophy and magnetization transfer ratio analyses from the EXPAND phase 3 trial

Validated writers and erasers can be quantified using in-vitro reconstitution with site-resolved proteomics and extended to chromatin-relevant contexts [43, 44, 59, 71, 78], and patient-oriented readouts can combine quantitative LCMS with standardized tissue assays and, where feasible, noninvasive measures of lactate flux [52, 88, 384, 391, 392]

doi: 10.1007/s11010-020-03719-5 45 WongRS

Deamidation accelerates at higher temperatures and at pH values outside the optimal range of 4 to 5 for storage formulations