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In nondiabetic patients, there is no specific or defined limit for normal serum glucose levels, and hypoglycemia is defined mainly by its clinical features

Starting too high causes : Severe nausea and vomiting Extreme fatigue Intolerable side effects Protocol abandonment Gradual titration : Minimizes side effects Allows adaptation Improves tolerance Maintains adherence Standard schedule : Start 2.5mg weekly, increase every 4 weeks until reaching maintenance dose

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