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In healthy adults, its activity declines with age, contributing to the progressive loss of synaptic density and cognitive flexibility that most people experience starting in their 40s and 50s

This statement applies especially to antidepressantsincrease from about 12 to 55 DDD/1000 inhabitants/day (from 1990 to 2014) (Norwegian Institute of Public Health 2015)

That's the manufacturer's guideline and the standard the research community follows

16 The Age-Related Eye Disease Study (AREDS), a landmark investigation conducted by the National Eye Institute, determined that specific antioxidant supplementation can slow the progression of AMD