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The PEPITEM-derived tripeptides mentioned earlier produced comparable efficacy to Clobetasol Propionate 0.05 percent, one of the strongest topical steroids, without the steroid-associated side effects

Since AgRP neurons are critically involved in neuroendocrine adaptations induced by weight loss 12, 16, 17 , control and AgRP GHR KO mice were further studied either in ad libitum or during 60% food restriction (F.R.)

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Subsequently, Western Blot (WB) analysis detected a decrease in total P53 expression but an increase in phosphorylated P53 (p-P53) expression in OGD-induced senescent endothelial cells post FOXO4-DRI treatment (Figures 5B,C)