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Pope Benedict XIV had the first tobacco factory built in Rome in the mid-18th century in the city's more rural Trastevere neighborhood where it was powered by water from a fountain on the Janiculum hill

Capodicasa G, Caponnetto P, Polosa R, Calogero AE

The following states have enacted laws banning smoking in workplace and personal motor vehicles with a child present (as of September 2020): Maine Vermont Virginia Illinois Arkansas Louisiana Utah California Oregon States with bans on smoking in workplace motor vehicles only include (as of September 2020): New Mexico Colorado North Dakota Nebraska Oklahoma Minnesota Iowa Indiana Ohio Tennessee North Carolina Pennsylvania Maryland Delaware New York Massachusetts Rhode Island

It also creates a significant economic burden