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Since DFO is membrane impermeable and accumulates in lysosomes 18 , we believe that it protects the cells against ferroptosis by chelating lysosomal iron as described previously 47

Furthermore, genome-wide CRISPR screening identified SEC24 homolog B (SEC24B) as a key regulator of ferroptosis, and its knockout significantly inhibited ferroptosis in microglia (Ryan et al., 2023b)