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While the functions of the HEAT-repeats are relatively well-understood 21 , the roles of the IDR, due to its structural flexibility, which prevents its visualization in cryo-EM structures, remains largely unclear 20

Many patients spend years navigating a maze of debilitating symptomsprofound fatigue, severe brain fog, unpredictable allergic reactions, and widespread painonly to be told their blood work is normal

2 Functional connectivity between subcortical regions and the cortical networks in Parkinsons disease (PD) patients