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10.1007/s11154-008-9087-z

We can say that it is likely that there is no 0 reading to be had from a living person but what we can't now say is what juanpablo111 's level actually was, or whether he was B12 deficient

The SURMOUNT-1 trial enrolled over 2,500 participants and tested three dose levels against placebo over 72 weeks

Most practitioners recommend starting at 250-300 mcg daily to assess tolerance, then potentially increasing to 400-500 mcg if initial response is suboptimal and no side effects occur