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During the synthesis process, the reaction conditions such as temperature, pH value and reagent concentration need to be precisely controlled

Challenges and Limitations Stability and Degradation Issues Peptide stability remains a fundamental challenge affecting both drug development and clinical use

However, disruption of this homeostatic relationship can cause diseases in which neutrophilic inflammation is central to the pathology, such as chronic obstructive pulmonary disease (COPD), alpha-1 antitrypsin deficiency, bronchiectasis, and cystic fibrosis, as well as many non-pulmonary pathologies

This multi-receptor approach is designed to produce greater weight reduction than dual or single agonists, as demonstrated in the 2023 phase 2 trial data