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The presence of ginkgolic acids is associated with cytotoxicity and allergenicity, underscoring the need to limit their concentration in commercial products (74)

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A peer-reviewed review summarized that in a human skin model, 250 g per tissue of alpha-arbutin reduced melanin content to 40% of the control without causing cell death , and another report found a related arbutin treatment reduced UVR-induced hyperpigmentation by 43.5% versus vehicle control , as summarized in this review on skin depigmenting agents

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