Comparing REW with an engineered Fc variant with enhanced CDC activity, but without half-life extension 43,55 , equal CDC activity against a hard-to-kill cell line was measured for recombinant versions of anti-CD20 ofatumumab (SI Text 5, Fig
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This compound assists in combating inflammation, predominantly by regulating nuclear factor-B (NF-B), which influences the survival, proliferation, angiogenesis, metastasis, and differentiation signaling cascade of cancer cells [164], and has proven highly useful in reducing inflammation and mitigating adverse effects during therapy [165]
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