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doi: 10.1080/19490976.2021.1922241 304 ZhaoJLiaoYWeiCMaYWangFChenYet al

However, functionally there are three redox states of CoQ, that is, fully oxidized (CoQ, UQ), partially reduced (a semiquinone anion radical with a reactive unpaired electron, CoQ , UQ ), and fully reduced (CoQH 2 , UQH 2 ) (4, 5) (FIGURE 1)

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These two studies pinpointed that the effects of cyst(e)ine depletion are not linear, but rather form an intertwined metabolic network to drive ferroptotic cell death