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Cellular effects duration vs plasma half-life Critical distinction: Plasma half-life duration of effects GHK-Cu clears blood in hours But cellular effects last days How GHK-Cu works: Peptide binds to cell surface receptors Triggers intracellular signaling cascades Activates gene expression changes Initiates collagen synthesis, wound healing, etc

Cimmino L, Dolgalev I, Wang Y et al (2017) Restoration of TET2 function blocks aberrant self-renewal and leukemia progression

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GSH: p = 0.0621, Cys: p = 0.0735) (d) or flank (WT, n = 4