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Since then, researchers have developed several variations of the said drugs to cater to as many patients with depression as possible.Some types or classes of antidepressants include: Selective serotonin reuptake inhibitors (SSRIs) Serotonin/norepinephrine reuptake inhibitors (SNRIs) Tricyclic antidepressants (TCAs) Atypical antidepressants Serotonin modulators Monoamine oxidase inhibitors (MAOIs) N-methyl-D-aspartate (NMDA) antagonists The most common type of prescribed antidepressant today is SSRIs