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Peroxiredoxins and beyond

Gq-ER, though still in the early stage of research with its tissue distribution not yet fully established, is involved in rapid signal transduction via Gq protein activation (29), while ER-X is known for its high-affinity binding in tissues like brain and uterus, particularly during postnatal development

While short-term fasting decreases serum IGF-I but does not affect GHBP (69), the triad of IGF-I deficiency, poor growth and pubertal delay/arrest in long term nutritional deficiency such as in anorexia nervosa is associated with low GHBP that is partly restored with weight gain (63)

Limongi et al recently showed that a GSH derivate (N-butanoyl glutathione, GSH-C4) is able to penetrate cell membranes and buffer GSH depletion, thus counteract on the pro-inflammatory response in different cellular models of inflammation, by reducing the expression of pro-inflammatory cytokines via NFkB modulation