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A comprehensive review of 36 studies (1993-2024) confirms effects on growth factor upregulation, VEGF/VEGFR2 expression, and FAK-paxillin cell migration pathways

Substitutions at other Mpro cleavage sites have not been associated with nirmatrelvir resistance in cell culture

Copper has long been associated with the formation of protease-resistant, -sheet enriched scrapie conformation of prion protein PrP Sc , which has been considered the critical step in the neurodegenerative prion diseases known as transmissible spongiform encephalopathies [43, 262]

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