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It is derived from the 176-191 amino acid sequence of human growth hormone (hGH), retaining the fat metabolism activity while eliminating the function of promoting growth

This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

Whether it's an in vitro cell study or an in vivo animal model, the desired outcomelike fat metabolism or NAD+ modulationwill dictate the appropriate concentration and administration schedule

In 2003, the famous Ralph Carmel wrote in the New England Journal of Medicine: The administration of folic acid can mask the megaloblastic anaemia caused by cobalamin deficiency