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This is rare with medically supervised, appropriately dosed treatment courses but underscores why baseline liver function assessment is important before starting

Identifying responders before treatment could improve outcomes and reduce failed treatment attempts

While its suppression alleviates chronic inflammation, complete inhibition of NF-B signaling has been shown to impair osteoblast proliferation, migration, and early differentiation, suggesting that its therapeutic targeting must be finely tuned in terms of dosage, timing, and pathway specificity

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